Opinion -: The balance between heritable and environmental aetiology of human disease

被引：114

作者：

Hemminki, Kari

Bermejo, Justo Lorenzo

Forsti, Asta

机构：

[1] Deutsch Krebsforschungszentrum, German Canc Res Ctr, Div Mol Genet Epidemiol, D-69120 Heidelberg, Germany

[2] Karolinska Inst, Ctr Family Med, S-14183 Huddinge, Sweden

来源：

NATURE REVIEWS GENETICS | 2006年 / 7卷 / 12期

关键词：

D O I：

10.1038/nrg2009

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The Human Genome Project and the ensuing International HapMap Project were largely motivated by human health issues. But the distance from a DNA sequence variation to a novel disease gene is considerable; for complex diseases, closing this gap hinges on the premise that they arise mainly from heritable causes. Using cancer as an example of complex disease, we examine the scientific evidence for the hypothesis that human diseases result from interactions between genetic variants and the environment.

引用

页码：958 / 965

页数：8

共 78 条

[1] A haplotype map of the human genome [J].

Altshuler, D ;

Brooks, LD ;

Chakravarti, A ;

Collins, FS ;

Daly, MJ ;

Donnelly, P ;

Gibbs, RA ;

Belmont, JW ;

Boudreau, A ;

Leal, SM ;

Hardenbol, P ;

Pasternak, S ;

Wheeler, DA ;

Willis, TD ;

Yu, FL ;

Yang, HM ;

Zeng, CQ ;

Gao, Y ;

Hu, HR ;

Hu, WT ;

Li, CH ;

Lin, W ;

Liu, SQ ;

Pan, H ;

Tang, XL ;

Wang, J ;

Wang, W ;

Yu, J ;

Zhang, B ;

Zhang, QR ;

Zhao, HB ;

Zhao, H ;

Zhou, J ;

Gabriel, SB ;

Barry, R ;

Blumenstiel, B ;

Camargo, A ;

Defelice, M ;

Faggart, M ;

Goyette, M ;

Gupta, S ;

Moore, J ;

Nguyen, H ;

Onofrio, RC ;

Parkin, M ;

Roy, J ;

Stahl, E ;

Winchester, E ;

Ziaugra, L ;

Shen, Y .

NATURE, 2005, 437 (7063) :1299-1320

[2] A common variant associated with prostate cancer in European and African populations [J].

Amundadottir, Laufey T. ;

Sulem, Patrick ;

Gudmundsson, Julius ;

Helgason, Agnar ;

Baker, Adam ;

Agnarsson, Bjarni A. ;

Sigurdsson, Asgeir ;

Benediktsdottir, Kristrun R. ;

Cazier, Jean-Baptiste ;

Sainz, Jesus ;

Jakobsdottir, Margret ;

Kostic, Jelena ;

Magnusdottir, Droplaug N. ;

Ghosh, Shyamali ;

Agnarsson, Kari ;

Birgisdottir, Birgitta ;

Le Roux, Louise ;

Olafsdottir, Adalheidur ;

Blondal, Thorarinn ;

Andresdottir, Margret ;

Gretarsdottir, Olafia Svandis ;

Bergthorsson, Jon T. ;

Gudbjartsson, Daniel ;

Gylfason, Arnaldur ;

Thorleifsson, Gudmar ;

Manolescu, Andrei ;

Kristjansson, Kristleifur ;

Geirsson, Gudmundur ;

Isaksson, Helgi ;

Douglas, Julie ;

Johansson, Jan-Erik ;

Balter, Katarina ;

Wiklund, Fredrik ;

Montie, James E. ;

Yu, Xiaoying ;

Suarez, Brian K. ;

Ober, Carole ;

Cooney, Kathleen A. ;

Gronberg, Henrik ;

Catalona, William J. ;

Einarsson, Gudmundur V. ;

Barkardottir, Rosa B. ;

Gulcher, Jeffrey R. ;

Kong, Augustine ;

Thorsteinsdottir, Unnur ;

Stefansson, Kari .

NATURE GENETICS, 2006, 38 (06) :652-658

[3] Cancer as a complex phenotype: Pattern of cancer distribution within and beyond the nuclear family [J].

Amundadottir, LT ;

Thorvaldsson, S ;

Gudbjartsson, DF ;

Sulem, P ;

Kristjansson, K ;

Arnason, S ;

Gulcher, JR ;

Bjornsson, J ;

Kong, A ;

Thorsteinsdottir, U ;

Stefansson, K .

PLOS MEDICINE, 2004, 1 (03) :229-236

[4] Cancer genetics - Common susceptibility genes for cancer: search for the end of the rainbow [J].

Baker, Stuart G. ;

Kaprio, Jaakko .

BMJ-BRITISH MEDICAL JOURNAL, 2006, 332 (7550) :1150-1152

[5] American Society of Clinical Oncology policy statement update: Genetic testing for cancer susceptibility [J].

Bruinooge, SS .

JOURNAL OF CLINICAL ONCOLOGY, 2003, 21 (12) :2397-2406

[6] Dissecting complex disease: the quest for the Philosopher's Stone? [J].

Buchanan, Anne V. ;

Weiss, Kenneth M. ;

Fullerton, Stephanie M. .

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2006, 35 (03) :562-571

[7] Genetics as a tool to improve cancer outcomes: ethics and policy [J].

Burke, W ;

Press, N .

NATURE REVIEWS CANCER, 2006, 6 (06) :476-482

[8] Key concepts in genetic epidemiology [J].

Burton, PR ;

Tobin, MD ;

Hopper, JL .

LANCET, 2005, 366 (9489) :941-951

[9] Opinion - Gene-environment interactions in psychiatry: joining forces with neuroscience [J].

Caspi, Avshalom ;

Moffitt, Terrie E. .

NATURE REVIEWS NEUROSCIENCE, 2006, 7 (07) :583-590

[10] Characterization of BRCA1 and BRCA2 mutations in a large United States sample [J].

Chen, SN ;

Iversen, ES ;

Friebel, T ;

Finkelstein, D ;

Weber, BL ;

Eisen, A ;

Peterson, LE ;

Schildkraut, JM ;

Isaacs, C ;

Peshkin, BN ;

Corio, C ;

Leondaridis, L ;

Tomlinson, G ;

Dutsm, D ;

Kerber, R ;

Amos, CI ;

Strong, LC ;

Berry, DA ;

Euthus, DM ;

Parmigiani, G .

JOURNAL OF CLINICAL ONCOLOGY, 2006, 24 (06) :863-871

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