Applying Undertaker to quality assessment

被引：7

作者：

Archie, John G. ^{[1
]}

Paluszewski, Martin ^{[2
]}

Karplus, Kevin ^{[1
]}

机构：

[1] Univ Calif Santa Cruz, Dept Biomol Engn, Santa Cruz, CA 95064 USA

[2] Univ Copenhagen, Bioinformat Ctr, DK-2200 Copenhagen, Denmark

来源：

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS | 2009年 / 77卷

关键词：

Undertaker; quality assessment; CASP; metaserver; PROTEIN-STRUCTURE PREDICTION; MODEL QUALITY; FOLD-RECOGNITION; CASP7;

D O I：

10.1002/prot.22508

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Our group tested three quality assessment functions in CASP8: a function which used only distance constraints derived from alignments (SAM-T08-MQAO), a function which added other single-model terms to the distance constraints (SAM-T08-MQAU), and a function which used both single-model and consensus terms (SAM-T08-MQAC). We analyzed the functions both for ranking models for a single target and for producing an accurate estimate of GDT_TS. Our functions were optimized for the ranking problem, so are perhaps more appropriate for metaserver applications than for providing trustworthiness estimates for single models. On the CASP8 test, the functions with more terms performed better. The MQAC consensus method was substantially better than either single-model function, and the MQAU function was substantially better than the MQAO function that used only constraints from alignments.

引用

页码：191 / 195

页数：5

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