2-Alkyloxyalkylthiohypoxanthines as new potent inhibitors of xanthine oxidase

被引：27

作者：

Biagi, G ^{[1
]}

Giorgi, I ^{[1
]}

Pacchini, F ^{[1
]}

Livi, O ^{[1
]}

Scartoni, V ^{[1
]}

机构：

[1] Univ Pisa, Dipartimento Sci Farmaceut, I-56100 Pisa, Italy

来源：

FARMACO | 2001年 / 56卷 / 11期

关键词：

xanthine oxidase; inhibitors; 2-thiohypoxanthine; 2-mercaptohypoxanthine; 2-thioxo-1,2,3,7(9)-tetrahydro-purin-6-one;

D O I：

10.1016/S0014-827X(01)01160-0

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

The title compounds were prepared and tested as xanthine oxidase (XO) inhibitors. Results evidenced that potency was related to the position of the oxygen atom in the 2-linear chain and that it grew with distance from the sulfur atom until it became equipotent to 2-n-hexylthiohypoxanthine. Enzymatic oxidation on C(2) occurred in the 8-alkylthiohypoxanthines. On the contrary, oxidation on C(8) did not occur in the 2-alkythioderivatives, demonstrating that the chain forced these molecules to form a complex with molybdenum(VI) involving only the N(3) and N(9) nitrogen atoms. (C) 2001 Elsevier Science S.A. All rights reserved.

引用

页码：809 / 813

页数：5

共 22 条

[1]

NEW SYNTHESES OF PURINE [J].