Preparation and characterization of chitosan microparticles intended for controlled drug delivery

Chitosan microparticles were prepared with tripolyphosphate (TPP) by ionic crosslinking. The particle sizes of TPP-chitosan microparticles were in range from 500 to 710 mum and encapsulation efficiencies of drug were more than 90%. The morphologies of TPP-chitosan microparticles were examined with scanning electron microscopy. As pH of TPP solution decreased and molecular weight (MW) of chitosan increased, microparticles had more spherical shape and smooth surface. Release behaviors of felodipine as a model drug were affected by various preparation processes. Chitosan microparticles prepared with lower pH or higher concentration of TPP solution resulted in slower felodipine release from microparticles. With decreasing NW and concentration of chitosan solution, release behavior was increased. The release of drug from TPP-chitosan microparticles decreased.when cross-linking time increased. These results indicate that TPP-chitosan microparticles may become a potential delivery is stem to control the release of drug. (C) 2002 Elsevier Science B.V. All rights reserved.