Total synthesis of (-)-epothilone B: An extension of the Suzuki coupling method and insights into structure-activity relationships of the epothilones

被引：152

作者：

Su, DS

Meng, DF

Bertinato, P

Balog, A

Sorensen, EJ

Danishefsky, SJ

Zheng, YH

Chou, TC

He, LF

Horwitz, SB

机构：

[1] SLOAN KETTERING INST CANC RES,BIOORGAN CHEM LAB,NEW YORK,NY 10021

[2] SLOAN KETTERING INST,BIOCHEM PHARMACOL LAB,NEW YORK,NY

[3] YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT MOL PHARMACOL,BRONX,NY 10461

[4] COLUMBIA UNIV,DEPT CHEM,NEW YORK,NY 10027

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1997年 / 36卷 / 07期

关键词：

antitumor agents; epothilone; natural products; total synthesis;

D O I：

10.1002/anie.199707571

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

[No abstract available]

引用

页码：757 / 759

页数：3

共 30 条

[1] Total synthesis of (-)-epothilone A
Balog, A
Meng, DF
Kamenecka, T
Bertinato, P
Su, DS
Sorensen, EJ
Danishefsky, S
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1996, 35 (23-24): : 2801 - 2803
[2] Balog A., 1996, Angew. Chem, V108, P2976
[3] Studies toward a synthesis of epothilone A: Stereocontrolled assembly of the acyl region and models for macrocyclization
Bertinato, P
Sorensen, EJ
Meng, DF
Danishefsky, SJ
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1996, 61 (23) : 8000 - 8001
[4] BOLLAG DM, 1995, CANCER RES, V55, P2325
[5] PREPARATION AND USE OF 1-IODOALKYL YLIDES
CHEN, J
WANG, T
ZHAO, K
[J]. TETRAHEDRON LETTERS, 1994, 35 (18) : 2827 - 2828
[6] CHOU J, 1987, IBM PC SOFTWARE MANU
[7] CHOU TC, 1991, SYNERGISM ANTAGONISM, P61
[8] TURBIDIMETRIC STUDIES OF INVITRO ASSEMBLY AND DISASSEMBLY OF PORCINE NEUROTUBULES
GASKIN, F
CANTOR, CR
SHELANSKI, ML
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1974, 89 (04) : 737 - +
[9] Hofle, 1996, ANGEW CHEM, V108, P1671, DOI DOI 10.1098/RSPA.2013.0690
[10] Epothilone A and B - Novel 16-membered macrolides with cytotoxic activity: Isolation, crystal structure, and conformation in solution
Hofle, GH
Bedorf, N
Steinmetz, H
Schomburg, D
Gerth, K
Reichenbach, H
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1996, 35 (13-14): : 1567 - 1569