Sequence analysis of the Rhop-3 gene of Plasmodium yoelii

被引：8

作者：

Anthony, RN

Yang, JC

Krall, JA

Sam-Yellowe, TY ^{[1
]}

机构：

[1] Cleveland State Univ, Dept Biol Geol & Environm Sci, Cleveland, OH 44115 USA

[2] FF10 Cleveland Clin Fdn, Dept Mol Cardiol, Cleveland, OH 44195 USA

[3] Amersham Pharmacia Bioteh, Cleveland, OH 44128 USA

来源：

JOURNAL OF EUKARYOTIC MICROBIOLOGY | 2000年 / 47卷 / 03期

关键词：

apical complex organelles; high molecular weight rhoptry protein complex; malaria; Plasmodium chabaudi; Plasmodium falciparum; Plasmodium yoelii; Rhop-3; protein; rhoptry organelles;

D O I：

10.1111/j.1550-7408.2000.tb00053.x

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The 110 kDn/Rhop-3 rhoptry protein of Plasmodium falciparum is non-covalently associated with two other proteins, the 140 kDa Rhop-1 and the 130 kDa Rhop-2. cDNAs encoding Rhop-3 from Plasmodium yoelii were isolated using rhoptry-specific antisera from Plasmodium falciparum. P. yoelii, and Plasmodium chabaudi. The cDNAs encoded peptides with partial homology to the C-terminal region (residues 541-861) of P. falciparum Rhop-3. Core regions of homology to the P. falciparum gene will be useful in determining the biological role of Rhop-3 and its potential as a vaccine candidate for malaria.

引用

页码：319 / 322

页数：4

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