Cytotoxic phenylpropanoids and an additional thapsigargin analogue isolated from Thapsia garganica

被引：36

作者：

Liu, Huizhen

Jensen, Kent Gunnertoft

Tran, Linh My

Chen, Ming

Zhai, Lin

Olsen, Carl Erik

Sohoel, Helmer

Denmeade, Samuel R.

Isaacs, John T.

Christensen, S. Brogger

机构：

[1] Danish Univ Pharmaceut Sci, Dept Med Chem, DK-2100 Copenhagen 0, Denmark

[2] Dept Clin Microbiol 7602, DK-2100 Copenhagen 0, Denmark

[3] Royal Vet & Agr Univ, Dept Nat Sci, DK-1870 Frederiksberg C, Denmark

[4] Johns Hopkins Univ, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA

来源：

PHYTOCHEMISTRY | 2006年 / 67卷 / 24期

关键词：

Thapsia garganica; Apiaceae; phenylpropanoids; 2,3-dihydroxy-2-methylbutanoic acid; relative configuration; cytotoxicity; thapsigargin;

D O I：

10.1016/j.phytochem.2006.10.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Four phenylpropanoids and a thapsigargin analogue have been isolated from the fruits of Thapsia garganica. A spectroscopic method for elucidating the relative stereochemistry at the two pairs of stereogenic centers in the phenylpropanoids has been developed. The phenylpropanoids were found to be potent cytotoxins. (c) 2006 Elsevier Ltd. All rights reserved.

引用

收藏

页码：2651 / 2658

页数：8

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