Novel DMARDs on the basis of a new concept of dual cytokine regulation, TNF-α suppression and IL-10 augmentation

被引：14

作者：

Hanano, T

Adachi, K

Aoki, Y

Morimoto, H

Naka, Y

Hisadome, M

Fukuda, T

Sumichika, H

机构：

[1] Yoshitomi Pharmaceut Ind Ltd, Div Pharmaceut Res, Drug Discovery Labs, Iruma, Saitama 3580026, Japan

[2] Yoshitomi Pharmaceut Ind Ltd, Div Pharmaceut Res, Drug Dev Labs, Yoshitomi, Fukuoka 8718550, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 09期

关键词：

D O I：

10.1016/S0960-894X(00)00129-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of arylpiperazine derivatives was synthesized to obtain agents showing apparent therapeutic effects in a chronic inflammatory animal model, starting from a lead possessing potent dual cytokine regulatory activity in vivo. We found a pyrimidylpiperazine derivative 17c showing the dual regulatory activity and an excellent therapeutic effect in an adjuvant-induced arthritis model. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：881 / 884

页数：4

共 6 条

[1] ENHANCED EXPRESSION OF TUMOR-NECROSIS-FACTOR RECEPTOR MESSENGER-RNA AND PROTEIN IN MONONUCLEAR-CELLS ISOLATED FROM RHEUMATOID-ARTHRITIS SYNOVIAL JOINTS [J].