Leptospira interrogans binds to the CR3 receptor on mammalian cells

被引：22

作者：

Cinco, M ^{[1
]}

Cini, B

Perticarari, S

Presani, G

机构：

[1] Univ Trieste, Spirochete Lab, Dipartimento Sci Biomed, I-34127 Trieste, Italy

[2] IRCCS, Lab Anal Clin, Trieste, Italy

来源：

MICROBIAL PATHOGENESIS | 2002年 / 33卷 / 06期

关键词：

leptospires; integrin; adhesion;

D O I：

10.1006/mpat.2002.0537

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Pathogenic leptospires adhere to phagocytes even in the absence of specific antibodies; we demonstrate that the CR3 integrin (known as Mac-1 or CD11b/CD18 receptor), expressed on neutrophils and CHO Mac-1 transfected cells, recognizes and binds leptospires. The 1-domain of the molecule seems to be involved in the recognition and data suggest that this occurs via fibronectin absorbed at the Leptospira surface. On the other hand, since N-acetyl-D-glucosamine does not behave as antagonist of the binding, the lectin-like domain of the receptor is not involved in the recognition. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：299 / 305

页数：7

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