Synthesis of 5,6-dihydro-4-hydroxy-2-pyrones as HIV-1 protease inhibitors: The profound effect of polarity on antiviral activity

被引：60

作者：

Hagen, SE

Prasad, JVNV

Boyer, FE

Domagala, JM

Ellsworth, EL

Gajda, C

Hamilton, HW

Markoski, LJ

Steinbaugh, BA

Tait, BD

Lunney, EA

Tummino, PJ

Ferguson, D

Hupe, D

Nouhan, C

Gracheck, SJ

Saunders, JM

VanderRoest, S

机构：

[1] PARKE DAVIS PHARMACEUT RES,DEPT BIOMOL STRUCT & DRUG DESIGN,ANN ARBOR,MI 48105

[2] PARKE DAVIS PHARMACEUT RES,DEPT BIOCHEM,ANN ARBOR,MI 48105

[3] PARKE DAVIS PHARMACEUT RES,DEPT INFECT DIS,ANN ARBOR,MI 48105

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1997年 / 40卷 / 23期

关键词：

D O I：

10.1021/jm970522y

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

[No abstract available]

引用

页码：3707 / 3711

页数：5

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