Gd(III)-Nanodiamond Conjugates for MRI Contrast Enhancement

被引：257

作者：

Manus, Lisa M. ^{[1
,2
,3
,4
,5
]}

Mastarone, Daniel J. ^{[1
,2
,3
,4
,5
]}

Waters, Emily A. ^{[1
,2
,3
,4
,5
]}

Zhang, Xue-Qing ^{[6
,7
]}

Schultz-Sikma, Elise A. ^{[1
,2
,3
,4
,5
]}

MacRenaris, Keith W. ^{[1
,2
,3
,4
,5
]}

Ho, Dean ^{[6
,7
]}

Meade, Thomas J. ^{[1
,2
,3
,4
,5
]}

机构：

[1] Northwestern Univ, Dept Chem, Evanston, IL 60208 USA

[2] Northwestern Univ, Dept Biochem, Evanston, IL 60208 USA

[3] Northwestern Univ, Dept Mol & Cell Biol, Evanston, IL 60208 USA

[4] Northwestern Univ, Dept Neurobiol & Physiol, Evanston, IL 60208 USA

[5] Northwestern Univ, Dept Radiol, Evanston, IL 60208 USA

[6] Northwestern Univ, Robert R McCormick Sch Engn & Appl Sci, Evanston, IL 60208 USA

[7] Northwestern Univ, Robert H Lurie Comprehens Canc Ctr, Feinberg Sch Med, Chicago, IL 60611 USA

来源：

NANO LETTERS | 2010年 / 10卷 / 02期

基金：

美国国家科学基金会;

关键词：

Nanodiamonds; nanomedicine; MR contrast agents; gadolinium; CARBON NANOTUBES; FLUORESCENT NANODIAMONDS; RELAXIVITY; GADOLINIUM; AGENTS; BIOCOMPATIBILITY; NANOMATERIALS; AGGREGATION; ADSORPTION; CHEMISTRY;

D O I：

10.1021/nl903264h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A Gd(III)-nanodiamond conjugate [Gd(III)-ND] was prepared and characterized, enabling detection of nanodiamonds by MR imaging. The Gd(III)-ND particles significantly reduced the T-1 of water protons with a per-Gd(III) relaxivity of 58.82 +/- 1.18 mM(-1) s(-1) at 1.5 T (60 MHz). This represents a 10-fold increase compared to the monomer Gd(III) complex (r(1) = 5.42 +/- 0.20 mM(-1) s(-1)) and is among the highest per-Gd(III) relaxivities reported.

引用

页码：484 / 489

页数：6

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