A Comparison of Prediction Equations for Estimating Glomerular Filtration Rate in Pregnancy

被引：31

作者：

Ahmed, Sofia B. ^{[1
]}

Bentley-Lewis, Rhonda ^{[2
,3
,4
]}

Hollenberg, Norman K. ^{[2
,3
,4
,5
]}

Graves, Steven W. ^{[6
]}

Seely, Ellen W. ^{[2
,3
,4
]}

机构：

[1] Univ Calgary, Foothills Med Ctr, Dept Med, Div Nephrol, Calgary, AB T2N 2T9, Canada

[2] Dept Med, Div Endocrinol, Boston, MA USA

[3] Dept Med, Div Hypertens, Boston, MA USA

[4] Dept Med, Div Diabet, Boston, MA USA

[5] Brigham & Womens Hosp, Boston, MA 02115 USA

[6] Brigham Young Univ, Dept Chem & Biochem, Provo, UT 84602 USA

来源：

HYPERTENSION IN PREGNANCY | 2009年 / 28卷 / 03期

基金：

美国国家卫生研究院;

关键词：

Pregnancy; Glomerular filtration rate; Prediction equation; Inulin clearance; Kidney; RENAL-FUNCTION; COCKCROFT-GAULT; CHRONIC KIDNEY; CYSTATIN-C; CREATININE; PROTEIN; HYPERTENSION; AGREEMENT; DYNAMICS; FORMULAS;

D O I：

10.1080/10641950801986720

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective: To compare existing glomerular filtration rate (GFR) prediction equations with the gold standard, inulin clearance, in pregnancy. Methods: Five equations were assessed for precision, bias, and accuracy in prediction of true GFR, measured by inulin clearance in 12 healthy, pregnant women during the second (T2) and third (T3) trimesters and in postpartum (PP). Results: Precision was greatest with 24-hour creatinine clearance estimation of GFR (R-2 = 13% (T2), R-2 = 26% (T3)). Other than 100/SCr, all equations underestimated true GFR. 30% accuracy was greatest in 100/SCr (83% (T2), 92% (T3)). Conclusions: Current GFR prediction formulae do not appear to be sufficient for estimating GFR in the gravid state.

引用

页码：243 / 255

页数：13

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