Family-based association study between brain-derived neurotrophic factor gene polymorphisms and attention deficit hyperactivity disorder in UK and Taiwanese samples

被引：50

作者：

Xu, Xiaohui ^{[1
]}

Mill, Jonathan ^{[1
]}

Zhou, Kaixin ^{[1
]}

Brookes, Keeley ^{[1
]}

Chen, Chih-Ken ^{[1
]}

Asherson, Philip ^{[1
]}

机构：

[1] Kings Coll London, MRC Social Genet & Dev Psychiat Ctr, Inst Psychiat, London SE5 8AF, England

来源：

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS | 2007年 / 144B卷 / 01期

基金：

英国惠康基金;

关键词：

brain-derived neurotrophic factor (BDNF); attention-deficit hyperactivity disorder (ADHD); association studies; single nucleotide polymorphism (SNP);

D O I：

10.1002/ajmg.b.30406

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Brain-derived neurotrophic factor (BDNF) plays an important role in normal neuronal development. Several lines of evidence implicate the involvement of BDNF in attention-deficit hyperactivity disorder (ADHD). This study investigated the role of two common BDNF variants (Va166Met, C270T) in two samples of ADHD probands from the United Kingdom (n=180) and Taiwan (n=212). We found evidence of increased transmission of the C allele of the C270T in Taiwanese samples (TDT: chi(2) = 6.78, P = 0.009) and the two samples pooled together (TDT: chi(2) = 7.24, P = 0.007). No association was found between the Va166Met polymorphism and ADHD in either of the two populations. Analysis of haplotypes demonstrated a significant decreased transmission of haplotypes containing the Va166 allele and the 270T allele in the Taiwanese samples (TDT: chi(2) = 4.57, P = 0.032) and the pooled sample set (TDT: chi(2) = 5.82, P=0.016). This study provides evidence for the possible involvement of BDNF in susceptibility to ADHD. (c) 2006 Wiley-Liss, Inc.

引用

页码：83 / 86

页数：4

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