Negative normal stress in semiflexible biopolymer gels

被引:323
作者
Janmey, Paul A.
Mccormick, Margaret E.
Rammensee, Sebastian
Leight, Jennifer L.
Georges, Penelope C.
Mackintosh, Fred C.
机构
[1] Univ Penn, Inst Med & Engn, Philadelphia, PA 19104 USA
[2] Univ Penn, Dept Phys & Astron, Philadelphia, PA 19104 USA
[3] Tech Univ Munich, Phys Dept E22 Biophys, D-85747 Garching, Germany
[4] Vrije Univ Amsterdam, Dept Phys & Astron, NL-1081 HV Amsterdam, Netherlands
基金
美国国家科学基金会; 美国国家卫生研究院;
关键词
D O I
10.1038/nmat1810
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
When subject to stress or external loads, most materials resist deformation. Any stable material, for instance, resists compression - even liquids. Solids also resist simple shear deformations that conserve volume. Under shear, however, most materials also have a tendency to expand in the direction perpendicular to the applied shear stress, a response that is known as positive normal stress(1). For example, wet sand tends to dilate when sheared, and therefore dries around our feet when we walk on the beach. In the case of simple solids, elastic rods or wires tend to elongate when subject to torsion(2). Here, we show that networks of semiflexible biopolymers such as those that make up both the cytoskeleton of cells and the extracellular matrix exhibit the opposite tendency: when sheared between two plates, they tend to pull the plates together. We show that these negative normal stresses can be as large as the shear stress and that this property is directly related to the nonlinear strain-stiffening behaviour of biopolymer gels(3).
引用
收藏
页码:48 / 51
页数:4
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