Glial cells and Parkinson's disease

被引：66

作者：

Hirsch, EC ^{[1
]}

机构：

[1] Hop La Pitie Salpetriere, INSERM U289, F-75013 Paris, France

来源：

JOURNAL OF NEUROLOGY | 2000年 / 247卷 / Suppl 2期

关键词：

apoptosis; cytokines; dopamine neuron; substantia nigra;

D O I：

10.1007/PL00007762

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Parkinson's disease is a neurodegenerative disease characterised by a massive loss of dopaminergic neurons in the substantia nigra. Yet glial cells may also participate in the pathophysiology of the disease. Indeed, glial cells can produce trophic factors which may stimulate neuronal survival or, alternatively, they could produce toxic compounds which may be involved in neuronal degeneration. This paper reviews the potentially protective or deleterious effects of glial cells in the substantia nigra of patients with Parkinson's disease.

引用

页码：58 / 62

页数：5

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