Fetal wound healing: Current biology

被引:205
作者
Bullard, KM
Longaker, MT
Lorenz, HP
机构
[1] Stanford Univ, Med Ctr, Dept Surg, Div Plast & Reconstruct Surg, Stanford, CA 94305 USA
[2] Univ Minnesota, Dept Surg, Div Colon & Rectal Surg, Minneapolis, MN 55455 USA
关键词
D O I
10.1007/s00268-002-6737-2
中图分类号
R61 [外科手术学];
学科分类号
摘要
The early-gestation fetus heals dermal wounds rapidly and scarlessly. This phenomenon appears to be intrinsic to fetal skin and independent of the intrauterine environment. Unique properties of fetal cells, extracellular matrix, cytokine profile, and gene expression contribute to scarless repair. An intensive research effort has focused on unraveling the mechanisms that underlie scarless fetal wound healing in an attempt to improve the quality of healing in both children and adults.
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收藏
页码:54 / 61
页数:8
相关论文
共 88 条
[1]  
ADZICK NS, 1985, J PEDIATR SURG, V20, P315
[2]   BIOLOGY OF FETAL WOUND-HEALING - HYALURONATE RECEPTOR EXPRESSION IN FETAL FIBROBLASTS [J].
ALAISH, SM ;
YAGER, D ;
DIEGELMANN, RF ;
COHEN, IK .
JOURNAL OF PEDIATRIC SURGERY, 1994, 29 (08) :1040-1043
[3]  
[Anonymous], FETAL WOUND HEALING
[4]   ONTOGENY OF THE SKIN AND THE TRANSITION FROM SCAR-FREE TO SCARRING PHENOTYPE DURING WOUND-HEALING IN THE POUCH YOUNG OF A MARSUPIAL, MONODELPHIS-DOMESTICA [J].
ARMSTRONG, JR ;
FERGUSON, MWJ .
DEVELOPMENTAL BIOLOGY, 1995, 169 (01) :242-260
[5]  
BEANES S, 2001, WOUND REPAIR REGEN, V9, P153
[6]   Down-regulation of decorin, a transforming growth factor-beta modulator, is associated with scarless fetal wound healing [J].
Beanes, SR ;
Dang, C ;
Soo, C ;
Wang, Y ;
Urata, M ;
Ting, K ;
Fonkalsrud, EW ;
Benhaim, P ;
Hedrick, MH ;
Atkinson, JB ;
Lorenz, HP .
JOURNAL OF PEDIATRIC SURGERY, 2001, 36 (11) :1666-1671
[7]  
BOL'SHAKOVA G B, 1990, Ontogenez, V21, P409
[8]   Transforming growth factor beta-1 decreases interstitial collagenase in healing human fetal skin [J].
Bullard, KM ;
Cass, DL ;
Banda, MJ ;
Adzick, NS .
JOURNAL OF PEDIATRIC SURGERY, 1997, 32 (07) :1023-1027
[9]   FETAL WOUND-HEALING IN A LARGE ANIMAL-MODEL - THE DEPOSITION OF COLLAGEN IS CONFIRMED [J].
BURD, DAR ;
LONGAKER, MT ;
ADZICK, NS ;
HARRISON, MR ;
EHRLICH, HP .
BRITISH JOURNAL OF PLASTIC SURGERY, 1990, 43 (05) :571-577
[10]  
Cass D. L., 1995, SURG FORUM, V47, P765