Nitazoxanide or CD3+/CD4+ lymphocytes for recovery from severe Cryptosporidium infection after allogeneic bone marrow transplant?

被引：12

作者：

Faraci, M.

Cappelli, B.

Morreale, G.

Lanino, E.

Moroni, C.

Bandettini, R.

Terranova, M. P.

Di Martino, D.

Coccia, C.

Castagnola, E.

机构：

[1] G Gaslini Childrens Hosp, Bone Marrow Transplantat Unit, Dept Hematol & Oncol, I-16147 Genoa, Italy

[2] G Gaslini Childrens Hosp, Infect Dis Unit, Dept Hematol & Oncol, I-16147 Genoa, Italy

[3] G Gaslini Childrens Hosp, Clin Pathol & Microbiol Lab, Dept Hematol & Oncol, I-16147 Genoa, Italy

[4] G Gaslini Childrens Hosp, Hematol Lab, Dept Hematol & Oncol, I-16147 Genoa, Italy

[5] G Gaslini Childrens Hosp, Serv Pathol, I-16147 Genoa, Italy

来源：

PEDIATRIC TRANSPLANTATION | 2007年 / 11卷 / 01期

关键词：

cryptosporidium; nitazoxanide; bone marrow transplantation; CD3+/CD4+lymphocytes;

D O I：

10.1111/j.1399-3046.2006.00622.x

中图分类号：

R72 [儿科学];

学科分类号：

100202 [儿科学];

摘要：

We describe a case of Cryptosporidium infection occurring in a child after allogeneic SCT for acute non-lymphoblastic leukemia. This patient presented an intestinal, biliar, and pancreatic Cryptosporidium disease associated with an intestinal aGvHD. The increase in CD3+/CD4+ cells secondary to the reduction of steroid therapy associated with the improvement of aGvHD and the use of antiparasitic treatments (especially nitazoxanide) improved the infection-related symptoms and led to a complete clearance of the Cryptosporidium.

引用

页码：113 / 116

页数：4

共 12 条

[1]

ATKINS JT, 2004, TXB PEDIAT INFECT DI, P2687

[2]

Efficacy of nitazoxanide and paromomycin in biliary tract cryptosporidiosis in an immunosuppressed gerbil model [J].