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Reactive oxygen species, mitochondria, apoptosis and aging

被引：408
作者：
Papa, S
Skulachev, VP
机构：
[1] MOSCOW MV LOMONOSOV STATE UNIV, AN BELOZERSKY INST PHYSICOCHEM BIOL, MOSCOW 119899, RUSSIA
[2] UNIV BARI, INST MED BIOCHEM & CHEM, I-70124 BARI, ITALY
来源：
MOLECULAR AND CELLULAR BIOCHEMISTRY | 1997年 / 174卷 / 1-2期
关键词：
mitochondrial metabolism; mitochondrial DNA; superoxide radicals;
D O I：
10.1023/A:1006873518427
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
In this paper, we shall review various antioxygen defense systems of the cell paying particular attention to those that prevent superoxide formation rather than scavenge already formed superoxide and its products. The role of uncoupled, decoupled and non-coupled respiration, mitochondrial pore, mitochondrion-linked apoptosis will be considered. Mitochondrial theory of aging will be regarded in context of reactive oxygen species-induced damage of mitochondrial DNA.
引用
收藏
页码：305 / 319
页数：15
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