A high field gradient magnet for magnetic drug targeting

被引:126
作者
Alexiou, Christoph [1 ]
Diehl, Dirk
Henninger, Peter
Iro, Heinrich
Roeckelein, Rudolf
Schmidt, Wolfgang
Weber, Horst
机构
[1] Univ Erlangen Nurnberg, Hals Nasen Ohren Klin, D-91054 Erlangen, Germany
[2] Siemens AG, Corpt Technol, D-91050 Erlangen, Germany
[3] Siemens AG, Med Solut, Med MR NBO, D-91052 Erlangen, Germany
关键词
cancer therapy; chemotherapy; ferrofluid; magnet design; magnetic field gradient; magnetic force; nanoparticles;
D O I
10.1109/TASC.2005.864457
中图分类号
TM [电工技术]; TN [电子技术、通信技术];
学科分类号
0808 ; 0809 ;
摘要
A magnet for Magnetic Drug Targeting was designed, built and tested. The magnet applies a magnetic force on ferrofluids coupled with therapeutic agents for medical and biological applications, e.g. for regional treatment of cancer. The application for cancer treatment requires a high magnetic field gradient in the application volume around and inside the tumor. Furthermore the magnet should have low mass and size combined with an appropriate geometry for easy handling and positioning near the patient, as well as a surface temperature below 40 degrees C. The gradient of the magnetic field, which determines the magnetic force for small single-domain ferromagnetic particles, ranges from 100 T/m at the pole tip to a minimum of 10 Urn in an application volume of (20 mm)(3) and points inwardly to the center of the pole tip.
引用
收藏
页码:1527 / 1530
页数:4
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