Stress-induced sleep deprivation modifies corticotropin releasing factor (CRF) levels and CRF binding in rat brain and pituitary

被引:51
作者
Fadda, P [1 ]
Fratta, W [1 ]
机构
[1] UNIV CAGLIARI,NATL RES COUNCIL,CTR NEUROPHARMACOL,I-09124 CAGLIARI,ITALY
关键词
sleep deprivation; corticotropin-releasing factor; limbic system; striatum; rat;
D O I
10.1006/phrs.1997.0155
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Electroencephalographic (EEG) studies have shown that corticotropin-releasing factor (CRF) administration induces EEG activation, decreases sleep time both in rats and humans and modifies the sleep pattern in sleep deprived rats. In the present study we have investigated whether CRF neuronal activity could be altered in a situation of disrupted sleep-wake cycle. Sleep deprivation (SD) was induced by keeping the rat for 72 h on a small platform (7 cm) surrounded by water. Immediately after the SD period rats were killed and CRF levels and CRF receptor binding were evaluated in different brain areas. A marked increase in CRF levels was present in the striatum (+224%), limbic areas (+144%) and pituitary (+42%) whereas the hypothalamic CRF content was reduced (-57%). A significant decrease in CRF binding was found in the striatum (-33%) and pituitary (-38%) of sleep deprived rats. These results indicate that CRF neuronal activity is stimulated by SD, suggesting that CRF might play an important role in the physiological regulation of the sleep-wake cycle and that an altered CRF neuronal activity might be involved in behavioral modifications related to sleep disturbances. (C) 1997 The Italian Pharmacological Society.
引用
收藏
页码:443 / 446
页数:4
相关论文
共 38 条
[1]  
ALBERT I, 1970, PSYCHOPHYSIOLOGY, V7, P552
[2]   INTRAVENTRICULAR CORTICOTROPIN-RELEASING FACTOR ENHANCES BEHAVIORAL-EFFECTS OF NOVELTY [J].
BRITTON, DR ;
KOOB, GF ;
RIVIER, J ;
VALE, W .
LIFE SCIENCES, 1982, 31 (04) :363-367
[3]  
BROWN MR, 1985, BRAIN RES, V328, P335
[4]   THE INFLUENCE OF SLEEP-DEPRIVATION ON THYROID-HORMONE METABOLISM IN RAT FRONTAL-CORTEX [J].
CAMPOSBARROS, A ;
KOHLER, R ;
MULLER, F ;
ERAVCI, M ;
MEINHOLD, H ;
WESEMANN, W ;
BAUMGARTNER, A .
NEUROSCIENCE LETTERS, 1993, 162 (1-2) :145-148
[5]   BEHAVIORAL-EVALUATION OF THE STRESS-INDUCED BY THE PLATFORM METHOD FOR SHORT-TERM PARADOXICAL SLEEP-DEPRIVATION IN RATS [J].
COLLANDREU, M ;
AYORAMASCARELL, L ;
TRULLASOLIVA, R ;
MORGADOBERNAL, I .
BRAIN RESEARCH BULLETIN, 1989, 22 (05) :825-828
[6]   PREVIOUS STRESS ALTERS CORTICOTROPIN-RELEASING FACTOR NEUROTRANSMISSION IN THE LOCUS-COERULEUS [J].
CURTIS, AL ;
PAVCOVICH, LA ;
GRIGORIADIS, DE ;
VALENTINO, RJ .
NEUROSCIENCE, 1995, 65 (02) :541-550
[7]   SLEEP-DEPRIVATION INCREASES DOPAMINE D1 RECEPTOR ANTAGONIST [H-3] SCH 23390 BINDING AND DOPAMINE-STIMULATED ADENYLATE-CYCLASE IN THE RAT LIMBIC SYSTEM [J].
DEMONTIS, MG ;
FADDA, P ;
DEVOTO, P ;
MARTELLOTTA, MC ;
FRATTA, W .
NEUROSCIENCE LETTERS, 1990, 117 (1-2) :224-227
[8]  
DESOUZA EB, 1987, J NEUROSCI, V7, P88
[9]   Dopamine receptor-mediated regulation of corticotropin-releasing hormone neurons in the hypothalamic paraventricular nucleus [J].
Eaton, MJ ;
Cheung, S ;
Moore, KE ;
Lookingland, KJ .
BRAIN RESEARCH, 1996, 738 (01) :60-66
[10]   EFFECTS OF CORTICOTROPIN-RELEASING FACTOR AND GROWTH HORMONE-RELEASING FACTOR ON SLEEP AND ACTIVITY IN RATS [J].
EHLERS, CL ;
REED, TK ;
HENRIKSEN, SJ .
NEUROENDOCRINOLOGY, 1986, 42 (06) :467-474