Role of interleukin-8 in onset of the immune response in intravesical BCG therapy for superficial bladder cancer

被引：56

作者：

deBoer, EC ^{[1
]}

Somogyi, L ^{[1
]}

deRuiter, GJW ^{[1
]}

deReijke, TM ^{[1
]}

Kurth, KH ^{[1
]}

Schamhart, DHJ ^{[1
]}

机构：

[1] UNIV PECS,SCH MED,DEPT UROL,H-7621 PECS,HUNGARY

来源：

UROLOGICAL RESEARCH | 1997年 / 25卷 / 01期

关键词：

interleukin-8; bacillus Calmette-Guerin; bladder carcinoma; urine;

D O I：

10.1007/BF00941903

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

In intravesical therapy for superficial bladder carcinoma urothelial cells may, through the production of cytokines, contribute to the bacillus Calmette-Guerin (BCG)-induced local immunological reaction and associated antitumor efficacy. The aim of this study was to investigate such a role for the neutrophil-attracting cytokine interleukin-8 (IL-8). The appearance of IL-8 in patients' urine after BCG therapy was compared with BCG-induced IL-6 and IL-2 and the stability of IL-8 in urine was tested. Compared to IL-6 and IL-2, a rapid induction of IL-8 was observed, occurring after the first BCG instillation. Urinary IL-8 was highly stable, even after 24 h incubation at 37 degrees C. The IL-8 concentration after the first instillation seemed to be associated with subsequent development of an immune response. Consequently, IL-8 seems an attractive candidate for investigation of its prognostic value for a clinical response to BCG therapy.

引用

页码：31 / 34

页数：4

共 14 条

[1] INTERLEUKIN-8 AND THE NEUTROPHIL RESPONSE TO MUCOSAL GRAM-NEGATIVE INFECTION [J].