A double-coated magnetite-based magnetic fluid evaluation by cytometry and genetic tests

被引：33

作者：

Freitas, MLL

Silva, LP

Azevedo, RB

Garcia, VAP

Lacava, LM

Grisólia, CK

Lucci, CM

Morais, PC

Da Silva, MF

Buske, N

Curi, R

Lacava, ZGM ^{[1
]}

机构：

[1] Univ Brasilia, Inst Ciencias Biol, Dept Genet & Morfol, BR-70910900 Brasilia, DF, Brazil

[2] Univ Brasilia, Inst Fis, BR-70919970 Brasilia, DF, Brazil

[3] Berlin Heart AG, D-12247 Berlin, Germany

[4] Univ Sao Paulo, Inst Ciencias Biol, BR-05508900 Sao Paulo, Brazil

来源：

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS | 2002年 / 252卷 / 1-3期

关键词：

biocompatibility; cytometry; magnetic fluid; magnetite; micronucleus;

D O I：

10.1016/S0304-8853(02)00655-8

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Magnetite nanoparticles pre-coated with dodecanoic acid and ethoxylated alcohol (DE) were used to obtain a physiologically stable magnetic fluid (DE-MF) sample. Three different doses of DE-MF were intraperitoneally applied to mice. Blood and peritoneum cytometry and micronucleus test were performed for 1-21 days after injection to investigate the DE-MF toxicity. Changes in cell population, peritoneum inflammation, and potential DE-MF genotoxic action were all time and dose dependent. At the lowest dose (5 x 10(15) particles/kg), DE-MF seems to be useful as a drug precursor with both diagnostic and therapeutic values. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：396 / 398

页数：3

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