Synthesis and biological properties of new glycosidic cationic lipids for DNA delivery

被引：24

作者：

Bessodes, M ^{[1
]}

Dubertret, C ^{[1
]}

Jaslin, G ^{[1
]}

Scherman, D ^{[1
]}

机构：

[1] CNRS, ENSCP, Lab Vectorol Mol & Cellulaire, UMR7001,Aventis Pharma Gencell, F-94403 Vitry Sur Seine, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 12期

关键词：

D O I：

10.1016/S0960-894X(00)00251-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Lipidic glycosides with amino alkyl pendent groups were synthesized and evaluated for in vitro DNA transfection activity. The first representative of this new class of cationic lipids showed good gene delivery and low toxicity to HeLa and 3T3 cells. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1393 / 1395

页数：3

共 18 条

[1] A FLEXIBLE APPROACH TO SYNTHETIC LIPID AMMONIUM-SALTS FOR POLYNUCLEOTIDE TRANSFECTION
BENNETT, MJ
MALONE, RW
NANTZ, MH
[J]. TETRAHEDRON LETTERS, 1995, 36 (13) : 2207 - 2210
[2] Cationic lipid-mediated gene delivery to murine lung: Correlation of lipid hydration with in vivo transfection activity
Bennett, MJ
Aberle, AM
Balasubramaniam, RP
Malone, JG
Malone, RW
Nantz, MH
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1997, 40 (25) : 4069 - 4078
[3] BESSODES M, 1988, SYNTHESIS-STUTTGART, P560
[4] Template oligomerization of DNA-Bound cations produces calibrated nanometric particles
Blessing, T
Remy, JS
Behr, JP
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1998, 120 (33) : 8519 - 8520
[5] Synthesis, activity, and structure-activity relationship studies of novel cationic lipids for DNA transfer
Byk, G
Dubertret, C
Escriou, V
Frederic, M
Jaslin, G
Rangara, R
Pitard, B
Crouzet, J
Wils, P
Schwartz, B
Scherman, D
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1998, 41 (02) : 224 - 235
[6] Cooper RG, 1998, CHEM-EUR J, V4, P137, DOI 10.1002/(SICI)1521-3765(199801)4:1<137::AID-CHEM137>3.0.CO
[7] 2-2
[8] FELGNER JH, 1994, J BIOL CHEM, V269, P2550
[9] LIPOFECTION - A HIGHLY EFFICIENT, LIPID-MEDIATED DNA-TRANSFECTION PROCEDURE
FELGNER, PL
GADEK, TR
HOLM, M
ROMAN, R
CHAN, HW
WENZ, M
NORTHROP, JP
RINGOLD, GM
DANIELSEN, M
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (21) : 7413 - 7417
[10] A NOVEL CATIONIC LIPOSOME REAGENT FOR EFFICIENT TRANSFECTION OF MAMMALIAN-CELLS
GAO, X
HUANG, L
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1991, 179 (01) : 280 - 285

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