INSULIN-LIKE GROWTH FACTOR-1 (IGF-1): RELATION WITH COGNITIVE FUNCTIONING AND NEUROIMAGING MARKER OF BRAIN DAMAGE IN A SAMPLE OF HYPERTENSIVE ELDERLY SUBJECTS

被引：32

作者：

Angelini, A. ^{[1
]}

Bendini, C. ^{[1
]}

Neviani, F. ^{[1
]}

Bergamini, L. ^{[1
]}

Manni, B. ^{[1
]}

Trenti, T. ^{[2
]}

Rovati, R. ^{[3
]}

Neri, M. ^{[1
]}

机构：

[1] Modena & Reggio Emilia Univ, Dept Geriatr, NOCSAE Nuovo Osped Civile S Agostino Estense, I-41100 Baggiovara, MO, Italy

[2] Univ Parma, Dept Psychol, Parma, PR, Italy

[3] NOCSAE Nuovo Osped Civile S Agostino Estense, Dept Neuroradiol, I-41100 Baggiovara, MO, Italy

来源：

ARCHIVES OF GERONTOLOGY AND GERIATRICS | 2009年 / 49卷

关键词：

Insulin-like growth factor-1 (IGF-1); Alzheimer's disease; cognitive decline; hypertensive elderly subjects; Cambridge cognitive examination (CAMDEX-R); frontal assessment battery (FAB); MESSENGER-RNA; SERUM-LEVELS; EXERCISE; EXPRESSION; INSULIN-LIKE-GROWTH-FACTOR-1; PROTEINS; HEALTH;

D O I：

10.1016/j.archger.2009.09.006

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

IGF-1 decline has been related to age-dependent cognitive impairment and dementia. No study examined IGF-1 levels in subjects with a risk factor for brain damage such as hypertension. We investigated the relationship between IGF-1, cognitive functioning and neuroimaging in a sample of 75 hypertensive elderly subjects aged > 65. Cognitive performance were tested by mini mental state examination (MMSE), Cambridge cognitive examination (CAMDEX-R), and the frontal assessment battery (FAB). Among other indices, free IGF-1 in serum was assayed. The radial width of the temporal horn (rWTH) evaluates medial cerebral temporal lobe atrophy. Significant correlations between IGF-1 levels and both total and sub-domain scores of cognition were found. IGF-1 level was significantly lower in cognitively declined group. The lowest IGF-1-percentile subgroup was significantly cognitively impaired. A statistically non-significant, but lower IGF-1 level was found in the sub-sample with pathologically wider rWTH. Levels of IGF-1 below 79.4 mu g/I are associated with cognitive decline, whereas a level above 118 mu g/I seems to be a marker of normal cognitive performance. A decreasing of IGF-1 related to a widening of the rWTH suggests an involvement of this hormone in hippocampus atrophy.

引用

页码：5 / 12

页数：8

共 37 条

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