Expression of Arnt and Arnt2 mRNA in developing murine tissues

被引：43

作者：

Aitola, MH

Pelto-Huikko, MT ^{[1
]}

机构：

[1] Tampere Univ, Dept Dev Biol, Sch Med, FIN-33014 Tampere, Finland

[2] Tampere Univ Hosp, Dept Pediat, Tampere, Finland

[3] Tampere Univ Hosp, Dept Pathol, Tampere, Finland

来源：

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY | 2003年 / 51卷 / 01期

关键词：

in situ hybridization; nervous system; immune system; respiratory tract; genitourinary tract; alimentary tract; endocrine organs; lymphatic organs; musculoskeletal system;

D O I：

10.1177/002215540305100106

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The basic helix-loop-helix (bHLH-PAS) proteins aryl hydrocarbon receptor nuclear translocator (Arnt) and Arnt2 are transcriptional regulators that function as dimerizing partners for several bHLH-PAS proteins and also some nonrelated partners. They are involved in various biological functions, including regulation of developmental genes. In earlier studies, the developmental expression of Arnt was reported to be almost ubiquitous, whereas Arnt2 expression has been shown to be more limited, comprising neuronal tissues as the main site of expression. Here we provide a detailed description of the expression of Arnt and Arnt2 mRNA in mouse tissues during embryonic and early postnatal development. Arnt and also Arnt2 transcripts, in contrast to earlier reports, are shown to be expressed more widely during development yet show a temporally and spatially specific pattern.

引用

页码：41 / 54

页数：14

共 40 条

[1] DEVELOPMENTAL EXPRESSION OF 2 MEMBERS OF A NEW CLASS OF TRANSCRIPTION FACTORS .2. EXPRESSION OF ARYL-HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR IN THE C57BL/6N MOUSE EMBRYO [J].