Molecular portraits and the family tree of cancer

被引：208

作者：

Chung, CH

Bernard, PS

Perou, CM

机构：

[1] Univ N Carolina, Lineberger Comprehens Canc Ctr, Dept Genet, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Lineberger Comprehens Canc Ctr, Dept Pathol & Lab Med, Chapel Hill, NC 27599 USA

[3] Univ N Carolina, Div Hematol Oncol, Chapel Hill, NC 27599 USA

[4] Univ Utah, Huntsman Canc Inst, Dept Pathol, Salt Lake City, UT 84112 USA

来源：

NATURE GENETICS | 2002年 / 32卷 / Suppl 4期

关键词：

D O I：

10.1038/ng1038

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学]; 090102 [作物遗传育种];

摘要：

The twenty-first century heralds a new era for the biological sciences and medicine. The tools of our time are allowing us to analyze complex genomes more comprehensively than ever before. A principal technology contributing to this explosion of information is the DNA microarray, which enables us to study genome-wide expression patterns in complex biological systems. Although the potential of microarrays is yet to be fully realized, these tools have shown great promise in deciphering complex diseases such as cancer. The early results are painting a detailed portrait of cancer that illustrates the individuality of each tumor and allows familial relationships to be recognized through the identification of cell types sharing common expression patterns.

引用

页码：533 / 540

页数：8

共 50 条

[1]

Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling [J].

Alizadeh, AA ;

Eisen, MB ;

Davis, RE ;

Ma, C ;

Lossos, IS ;

Rosenwald, A ;

Boldrick, JG ;

Sabet, H ;

Tran, T ;

Yu, X ;

Powell, JI ;

Yang, LM ;

Marti, GE ;

Moore, T ;

Hudson, J ;

Lu, LS ;

Lewis, DB ;

Tibshirani, R ;

Sherlock, G ;

Chan, WC ;

Greiner, TC ;

Weisenburger, DD ;

Armitage, JO ;

Warnke, R ;

Levy, R ;

Wilson, W ;

Grever, MR ;

Byrd, JC ;

Botstein, D ;

Brown, PO ;

Staudt, LM .

NATURE, 2000, 403 (6769) :503-511

[2]

Broad patterns of gene expression revealed by clustering analysis of tumor and normal colon tissues probed by oligonucleotide arrays [J].

Alon, U ;

Barkai, N ;

Notterman, DA ;

Gish, K ;

Ybarra, S ;

Mack, D ;

Levine, AJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (12) :6745-6750

[3]

Gene-expression profiles predict survival of patients with lung adenocarcinoma [J].

Beer, DG ;

Kardia, SLR ;

Huang, CC ;

Giordano, TJ ;

Levin, AM ;

Misek, DE ;

Lin, L ;

Chen, GA ;

Gharib, TG ;

Thomas, DG ;

Lizyness, ML ;

Kuick, R ;

Hayasaka, S ;

Taylor, JMG ;

Iannettoni, MD ;

Orringer, MB ;

Hanash, S .

NATURE MEDICINE, 2002, 8 (08) :816-824

[4]

Metastasis genes: A progression puzzle [J].

Bernards, R ;

Weinberg, RA .

NATURE, 2002, 418 (6900) :823-823

[5]

Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses [J].

Bhattacharjee, A ;

Richards, WG ;

Staunton, J ;

Li, C ;

Monti, S ;

Vasa, P ;

Ladd, C ;

Beheshti, J ;

Bueno, R ;

Gillette, M ;

Loda, M ;

Weber, G ;

Mark, EJ ;

Lander, ES ;

Wong, W ;

Johnson, BE ;

Golub, TR ;

Sugarbaker, DJ ;

Meyerson, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (24) :13790-13795

[6]

Gene expression patterns in human liver cancers [J].

Chen, X ;

Cheung, ST ;

So, S ;

Fan, ST ;

Barry, C ;

Higgins, J ;

Lai, KM ;

Ji, JF ;

Dudoit, S ;

Ng, IOL ;

van de Rijn, M ;

Botstein, D ;

Brown, PO .

MOLECULAR BIOLOGY OF THE CELL, 2002, 13 (06) :1929-1939

[7]

Fundamentals of experimental design for cDNA microarrays [J].

Churchill, GA .

NATURE GENETICS, 2002, 32 (Suppl 4) :490-495

[8]

Clinical management of gastrointestinal stromal tumors: Before and after STI-571 [J].

DeMatteo, RP ;

Heinrich, MC ;

El-Rifai, WM ;

Demetri, G .

HUMAN PATHOLOGY, 2002, 33 (05) :466-477

[9]

Delineation of prognostic biomarkers in prostate cancer [J].

Dhanasekaran, SM ;

Barrette, TR ;

Ghosh, D ;

Shah, R ;

Varambally, S ;

Kurachi, K ;

Pienta, KJ ;

Rubin, MA ;

Chinnaiyan, AM .

NATURE, 2001, 412 (6849) :822-826

[10]

Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the philadelphia chromosome. [J].

Druker, BJ ;

Sawyers, CL ;

Kantarjian, H ;

Resta, DJ ;

Reese, SF ;

Ford, JM ;

Capdeville, R ;

Talpaz, M .

NEW ENGLAND JOURNAL OF MEDICINE, 2001, 344 (14) :1038-1042

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