Gene transfer using replication-defective human foamy virus vectors

被引：28

作者：

Bieniasz, PD

Erlwein, O

Aguzzi, A

Rethwilm, A

McClure, MO

机构：

[1] IMPERIAL COLL ST MARYS,SCH MED,DEPT GU MED & COMMUNICABLE DIS,LONDON W2 1PG,ENGLAND

[2] UNIV ZURICH HOSP,DEPT PATHOL,INST NEUROPATHOL,CH-8091 ZURICH,SWITZERLAND

[3] UNIV WURZBURG,INST VIROL & IMMUNBIOL,D-8700 WURZBURG,GERMANY

来源：

VIROLOGY | 1997年 / 235卷 / 01期

基金：

英国惠康基金;

关键词：

D O I：

10.1006/viro.1997.8658

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Replication-defective vectors based on an infectious molecular clone of human foamy virus (HFV) were constructed by deletion and replacement of the accessory genes with expression cassettes for puromycin-resistance and beta-glucouronidase. Cell lines which produced in excess of 10(5) helper virus-free transducing units/ml were generated by trans-complementation of the replication defect using a BHK-21-derived cell line expressing the Bel-1 transactivator. Vectors based on the HFV genome may provide useful alternatives to existing retroviral vectors. (C) 1997 Academic Press.

引用

收藏

页码：65 / 72

页数：8

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