Highly Enantioselective and Organocatalytic α-Amination of 2-Oxindoles

被引：193

作者：

Cheng, Liang ^{[1
]}

Liu, Li ^{[1
]}

Wang, Dong ^{[1
]}

Chen, Yong-Jun ^{[1
]}

机构：

[1] Chinese Acad Sci, Inst Chem, CAS Key Lab Mol Recognit & Funct, BNLMS, Beijing 100190, Peoples R China

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 17期

基金：

中国国家自然科学基金;

关键词：

CATALYZED ASYMMETRIC ALLYLATION; CHIRAL LEWIS-BASE; BETA-KETO-ESTERS; CINCHONA ALKALOIDS; QUATERNARY; 3-AMINOOXINDOLES; PHOSPHONIUM SALTS; OXINDOLES; ALKYLATION; LIGANDS; DIHYDROXYLATION;

D O I：

10.1021/ol901405r

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An effective method for the asymmetric synthesis of 3-amino-2-oxindoles was developed. The tetrasubstituted chiral carbon center was generated by asymmetric amination of N-unprotected 2-oxindoles with azodicarboxylate catalyzed by commercial biscinchona alkaloids In good to excellent yields with high enantioselectivities.

引用

页码：3874 / 3877

页数：4

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