Major cell death pathways at a glance

被引：322

作者：

Duprez, Linde ^{[1
,2
]}

Wirawan, Ellen ^{[1
,2
]}

Vanden Berghe, Tom ^{[1
,2
]}

Vandenabeele, Peter ^{[1
,2
]}

机构：

[1] VIB, Dept Mol Biomed Res, Unit Mol Signaling & Cell Death, B-9052 Ghent, Zwijnaarde, Belgium

[2] Univ Ghent, Dept Biomed Mol Biol, Unit Mol Signaling & Cell Death, B-9052 Ghent, Zwijnaarde, Belgium

来源：

MICROBES AND INFECTION | 2009年 / 11卷 / 13期

关键词：

Apoptosis; Necrosis; Autophagy; Pyroptosis; RECEPTOR-INTERACTING PROTEIN; PERMEABILITY TRANSITION PORE; MOLECULAR-MECHANISMS; PROGRAMMED NECROSIS; APOPTOTIC CELLS; CYTOPLASMIC DNA; NEURONAL DEATH; KINASE RIP; TNF-ALPHA; AUTOPHAGY;

D O I：

10.1016/j.micinf.2009.08.013

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cell death is a crucial process during development, homeostasis and immune regulation of multicellular organisms, and its dysregulation is associated with numerous pathologies. Cell death is often induced upon pathogen infection as part of the defense mechanism, and pathogens have evolved strategies to modulate host cell death. In this review, we will discuss the molecular mechanisms and physiological relevance of four major types of programmed cell death, namely apoptosis. necrosis, autophagic cell death and pyroptosis. (C) 2009 Elsevier Masson SAS. All rights reserved.

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页码：1050 / 1062

页数：13

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