Major cell death pathways at a glance

被引：322

作者：

Duprez, Linde ^{[1
,2
]}

Wirawan, Ellen ^{[1
,2
]}

Vanden Berghe, Tom ^{[1
,2
]}

Vandenabeele, Peter ^{[1
,2
]}

机构：

[1] VIB, Dept Mol Biomed Res, Unit Mol Signaling & Cell Death, B-9052 Ghent, Zwijnaarde, Belgium

[2] Univ Ghent, Dept Biomed Mol Biol, Unit Mol Signaling & Cell Death, B-9052 Ghent, Zwijnaarde, Belgium

来源：

MICROBES AND INFECTION | 2009年 / 11卷 / 13期

关键词：

Apoptosis; Necrosis; Autophagy; Pyroptosis; RECEPTOR-INTERACTING PROTEIN; PERMEABILITY TRANSITION PORE; MOLECULAR-MECHANISMS; PROGRAMMED NECROSIS; APOPTOTIC CELLS; CYTOPLASMIC DNA; NEURONAL DEATH; KINASE RIP; TNF-ALPHA; AUTOPHAGY;

D O I：

10.1016/j.micinf.2009.08.013

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cell death is a crucial process during development, homeostasis and immune regulation of multicellular organisms, and its dysregulation is associated with numerous pathologies. Cell death is often induced upon pathogen infection as part of the defense mechanism, and pathogens have evolved strategies to modulate host cell death. In this review, we will discuss the molecular mechanisms and physiological relevance of four major types of programmed cell death, namely apoptosis. necrosis, autophagic cell death and pyroptosis. (C) 2009 Elsevier Masson SAS. All rights reserved.

引用

收藏

页码：1050 / 1062

页数：13

相关论文

共 86 条

[71] The history of Z-VAD-FMK, a tool for understanding the significance of caspase inhibition [J].

Van Noorden, CJF .

ACTA HISTOCHEMICA, 2001, 103 (03) :241-251

[72] Necrosis is associated with IL-6 production but apoptosis is not [J].

Vanden Berghe, T ;

Kalai, M ;

Denecker, G ;

Meeus, A ;

Saelens, X ;

Vandenabeele, P .

CELLULAR SIGNALLING, 2006, 18 (03) :328-335

[73]

VANDENABEELE P, 2006, SCI STKE, pE44

[74] Molecular mechanisms and pathophysiology of necrotic cell death [J].

Vanlangenakker, Nele ;

Vanden Berghe, Tom ;

Krysko, Dmitri V. ;

Festjens, Nele ;

Vandenabeele, Peter .

CURRENT MOLECULAR MEDICINE, 2008, 8 (03) :207-220

[75] TNF-α induces two distinct caspase-8 activation pathways [J].

Wang, Lai ;

Du, Fenghe ;

Wang, Xiaodong .

CELL, 2008, 133 (04) :693-703

[76] JNK1-mediated phosphorylation of BcI-2 regulates starvation-induced autophagy [J].

Wei, Yongjie ;

Pattingre, Sophie ;

Sinha, Sangita ;

Bassik, Michael ;

Levine, Beth .

MOLECULAR CELL, 2008, 30 (06) :678-688

[77] Microbial pathogen-induced necrotic cell death mediated by the inflammasome components CIAS1/Cryopyrin/NLRP3 and ASC [J].

Willingham, Stephen B. ;

Bergstralh, Daniel T. ;

O'Connor, William ;

Morrison, Amy C. ;

Taxman, Debra J. ;

Duncan, Joseph A. ;

Barnoy, Shoshana ;

Venkatesan, Malabi Im. ;

Flavell, Richard A. ;

Deshmukh, Mohanish ;

Hoffman, Hal M. ;

Ting, Jenny P. -Y. .

CELL HOST & MICROBE, 2007, 2 (03) :147-159

[78] Death receptor signal transducers: nodes of coordination in immune signaling networks [J].

Wilson, Nicholas S. ;

Dixit, Vishva ;

Ashkenazi, Avi .

NATURE IMMUNOLOGY, 2009, 10 (04) :348-355

[79] Autophagy plays a protective role during zVAD-induced necrotic cell death [J].

Wu, You-Tong ;

Tan, Hui-Ling ;

Huang, Qing ;

Kim, You-Sun ;

Pan, Ning ;

Ong, Wei-Yi ;

Liu, Zheng-Gang ;

Ong, Choon-Nam ;

Shen, Han-Ming .

AUTOPHAGY, 2008, 4 (04) :457-466

[80] Autophagosome formation: Core machinery and adaptations [J].

Xie, Zhiping ;

Klionsky, Daniel J. .

NATURE CELL BIOLOGY, 2007, 9 (10) :1102-1109

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