1H-MR spectroscopy and gray matter volume of the anterior cingulate cortex in schizophrenia

被引：61

作者：

Yamasue, H

Fukui, T

Fukuda, R

Yamada, H

Yamasaki, S

Kuroki, N

Obe, O

Kasai, K

Tsujii, K

Iwanami, A

Aoki, S

Ohtomo, K

Kato, N

Kato, T

机构：

[1] Univ Tokyo, Grad Sch Med, Dept Neuropsychiat, Bunkyo Ku, Tokyo 1138655, Japan

[2] Univ Tokyo, Grad Sch Med, Dept Radiol, Bunkyo Ku, Tokyo 1138655, Japan

[3] Univ Tokyo, Grad Sch Med, Dept Life Sci, Bunkyo Ku, Tokyo 1138655, Japan

[4] Harvard Univ, Sch Med, Dept Psychiat, Clin Neurosci Div,Lab Neurosci, Boston, MA 02115 USA

[5] RIKEN, Lab Mol Dynam Mental Disorders, Brain Sci Inst, Wako, Saitama 35101, Japan

来源：

NEUROREPORT | 2002年 / 13卷 / 16期

关键词：

anterior cingulate; blunted affect; choline; gray matter volume; magnetic resonance imaging (MRI); magnetic resonance spectroscopy (MRS); NAA; schizophrenia;

D O I：

10.1097/00001756-200211150-00029

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Schizophrenic and normal control subjects were examined using both H-1-magnetic resonance spectroscopy (MRS) and structural MR imaging, in order to accurately assess the partial volume within the spectroscopic volume of interest (VOI) in the anterior cingulate cortex. The gray matter volume within VOI correlated positively with the N-acetyl-aspartate (NAA) to choline (Cho) ratio in schizophrenics only, not in controls. Schizophrenic patients had a reduced NAA/Cho ratio and an elevated Cho/creatine ratio compared to controls after the partial volume effect was eliminated. There was a significant negative correlation between the NAA/Cho ratio and the severity of blunted affect symptom in schizophrenics. These results provide further support to the idea that the measures of H-1-MRS indicate not only neuronal loss but also neuronal dysfunction in schizophrenia.

引用

页码：2133 / 2137

页数：5

共 26 条

[1] Reduced NAA in the thalamus and altered membrane and glial metabolism in schizophrenic patients detected by 1H-MRS and tissue segmentation [J].