Despite epitope spreading in the pathogenesis of autoimmune disease, highly restricted approaches to immune therapy may still succeed [with a hedge on this bet]

被引:12
作者
Steinman, L [1 ]
机构
[1] Stanford Univ, Beckman Ctr Mol Med B002, Dept Neurol Sci, Stanford, CA 94305 USA
关键词
D O I
10.1006/jaut.2000.0379
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
[No abstract available]
引用
收藏
页码:278 / 282
页数:5
相关论文
共 43 条
[1]   LIMITED HETEROGENEITY OF T-CELL RECEPTORS FROM LYMPHOCYTES MEDIATING AUTOIMMUNE ENCEPHALOMYELITIS ALLOWS SPECIFIC IMMUNE INTERVENTION [J].
ACHAORBEA, H ;
MITCHELL, DJ ;
TIMMERMANN, L ;
WRAITH, DC ;
TAUSCH, GS ;
WALDOR, MK ;
ZAMVIL, SS ;
MCDEVITT, HO ;
STEINMAN, L .
CELL, 1988, 54 (02) :263-273
[2]   CELLULAR-IMMUNITY TO A DETERMINANT COMMON TO GLUTAMATE-DECARBOXYLASE AND COXSACKIE-VIRUS IN INSULIN-DEPENDENT DIABETES [J].
ATKINSON, MA ;
BOWMAN, MA ;
CAMPBELL, L ;
DARROW, BL ;
KAUFMAN, DL ;
MACLAREN, NK .
JOURNAL OF CLINICAL INVESTIGATION, 1994, 94 (05) :2125-2129
[3]   IDENTIFICATION OF THE 64K AUTOANTIGEN IN INSULIN-DEPENDENT DIABETES AS THE GABA-SYNTHESIZING ENZYME GLUTAMIC-ACID DECARBOXYLASE [J].
BAEKKESKOV, S ;
AANSTOOT, HJ ;
CHRISTGAU, S ;
REETZ, A ;
SOLIMENA, M ;
CASCALHO, M ;
FOLLI, F ;
RICHTEROLESEN, H ;
CAMILLI, PD .
NATURE, 1990, 347 (6289) :151-156
[4]   Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein [J].
Brocke, S ;
Gijbels, K ;
Allegretta, M ;
Ferber, I ;
Piercy, C ;
Blankenstein, T ;
Martin, R ;
Utz, U ;
Karin, N ;
Mitchell, D ;
Veromaa, T ;
Waisman, A ;
Gaur, A ;
Conlon, P ;
Ling, N ;
Fairchild, PJ ;
Wraith, DC ;
OGarra, A ;
Fathman, CG ;
Steinman, L .
NATURE, 1996, 379 (6563) :343-346
[5]   TYPE-I DIABETES - A CHRONIC AUTOIMMUNE-DISEASE OF HUMAN, MOUSE, AND RAT [J].
CASTANO, L ;
EISENBARTH, GS .
ANNUAL REVIEW OF IMMUNOLOGY, 1990, 8 :647-679
[6]   Exploring the potential of DNA vaccination [J].
Cohen, IR ;
Steinman, L .
HOSPITAL PRACTICE, 1997, 32 (05) :169-&
[7]   REACTIVITY TO MYELIN ANTIGENS IN MULTIPLE-SCLEROSIS - PERIPHERAL-BLOOD LYMPHOCYTES RESPOND PREDOMINANTLY TO MYELIN OLIGODENDROCYTE GLYCOPROTEIN [J].
DEROSBO, NK ;
MILO, R ;
LEES, MB ;
BURGER, D ;
BERNARD, CCA ;
BENNUN, A .
JOURNAL OF CLINICAL INVESTIGATION, 1993, 92 (06) :2602-2608
[8]   Predominance of the autoimmune response to myelin oligodendrocyte glycoprotein (MOG) in multiple sclerosis: reactivity to the extracellular domain of MOG is directed against three main regions [J].
deRosbo, NK ;
Hoffman, M ;
Mendel, I ;
Yust, I ;
Kaye, J ;
Bakimer, R ;
Flechter, S ;
Abramsky, O ;
Milo, R ;
Karni, A ;
BenNun, A .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1997, 27 (11) :3059-3069
[9]   DISQUISITIONS ON ORIGINAL ANTIGENIC SIN .I. EVIDENCE IN MAN [J].
DESTGROTH, SF ;
WEBSTER, RG .
JOURNAL OF EXPERIMENTAL MEDICINE, 1966, 124 (03) :331-+
[10]   VACCINATION AGAINST AUTOIMMUNE MOUSE DIABETES WITH A T-CELL EPITOPE OF THE HUMAN 65-KDA HEAT-SHOCK PROTEIN [J].
ELIAS, D ;
RESHEF, T ;
BIRK, OS ;
VANDERZEE, R ;
WALKER, MD ;
COHEN, IR .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (08) :3088-3091