Amyloid beta protein and transthyretin, sequestrating protein colocalize in normal human kidney

被引：15

作者：

Tsuzuki, K

Fukatsu, R

Hayashi, Y

Yoshida, T

Sasaki, N

Takamaru, Y

Yamaguchi, H

Tateno, M

Fujii, N

Takahata, N

机构：

[1] SAPPORO MED UNIV,DEPT NEUROPSYCHIAT,SCH MED,SAPPORO,HOKKAIDO 060,JAPAN

[2] SAPPORO CITY GEN HOSP,DEPT PSYCHIAT,SAPPORO,HOKKAIDO 062,JAPAN

[3] GUNMA UNIV,COLL MED CARE & TECHNOL,GUNMA 371,JAPAN

[4] SAPPORO CITY GEN HOSP,DEPT PATHOL,SAPPORO,HOKKAIDO 060,JAPAN

来源：

NEUROSCIENCE LETTERS | 1997年 / 222卷 / 03期

关键词：

amyloid beta protein; amyloid precursor protein; proximal renal tubules; distal renal tubules human kidney; end-specific antibody; transthyretin;

D O I：

10.1016/S0304-3940(97)13369-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The localization of amyloid beta protein (A beta), A beta 40, A beta 42, and transthyretin (TTR) was investigated immunohistochemically in the autopsied human kidney, using polyclonal antibodies against TTR, A beta and C-terminal end-specific antibodies against A beta 40 and 42. Immunoreactivities of A beta and A beta 40 were found both in the proximal and distal tubular epithelial cells. But the immunolocalization of A beta 40 was observed predominantly in the distal tubules whereas that of A beta 42 was predominantly recognized in the proximal tubules. TTR, sequestrating protein for A beta, was present in the proximal tubules. The mechanism by which A beta does not form amyloid in Alzheimer's disease outside the brain remains unknown. The tubular epithelial cells in the kidney may provide a useful system to shed light on this issue. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：163 / 166

页数：4

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