Correlations between measures of atherosclerosis change using carotid ultrasonography and coronary angiography

被引:96
作者
Mack, WJ [1 ]
LaBree, L
Liu, CR
Liu, CH
Selzer, RH
Hodis, HN
机构
[1] Univ So Calif, Atherosclerosis Res Unit, Los Angeles, CA 90089 USA
[2] Univ So Calif, Dept Prevent Med, Los Angeles, CA 90089 USA
[3] Univ So Calif, Dept Med, Los Angeles, CA 90089 USA
[4] CALTECH, Jet Prop Lab, Pasadena, CA 91125 USA
关键词
atherosclerosis; angiography; ultrasonography; coronary disease; carotid arteries;
D O I
10.1016/S0021-9150(99)00383-4
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Few studies have examined the correlation between change in carotid artery intima-media thickness (IMT) and change in coronary artery disease. In the Cholesterol Lowering Atherosclerosis Study, current nonsmoking men with coronary artery disease were randomized to colestipol-niacin or placebo. Among 133 subjects with baseline and on-trial coronary angiography and carotid ultrasonography, colestipol-niacin treatment significantly reduced progression of atherosclerosis by both end point measures (2-year average change in percent diameter stenosis by coronary angiography and rate of change in carotid IMT). Significant correlations between change in common carotid artery IMT and quantitative coronary angiographic measures of change were evident over all coronary artery lesions, and in mild/moderate (< 50% diameter stenosis), but not severe (greater than or equal to 50% diameter stenosis) coronary artery lesions. In mild/moderate lesions, correlations with change in common carotid IMT were: percent diameter stenosis (r = 0.28, P = 0.002), minimum lumen diameter (r = - 0.28, P = 0.002), and vessel edge roughness (r = 0.25, P = 0.003). While measures obtained by carotid ultrasonography and coronary angiography are correlated, they each assess different aspects of atherosclerosis change. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:371 / 379
页数:9
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