The imidazoline receptor in control of blood pressure by clonidine and allied drugs

被引：12

作者：

Reis, DJ

Piletz, JE

机构：

[1] UNIV MISSISSIPPI, MED CTR, DEPT PSYCHIAT & HUMAN BEHAV, JACKSON, MS 39216 USA

[2] UNIV MISSISSIPPI, MED CTR, DEPT PHARMACOL, JACKSON, MS 39216 USA

[3] UNIV MISSISSIPPI, MED CTR, DEPT PHYSIOL, JACKSON, MS 39216 USA

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY | 1997年 / 273卷 / 05期

关键词：

ventrolateral medulla; arterial pressure; alpha(2)-adrenergic receptors;

D O I：

10.1152/ajpregu.1997.273.5.R1569

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Clonidine, moxonidine, and rilmenidine are centrally acting antihypertensive agents that lower arterial pressure by inhibiting the tonic activity of sympathoexcitatory neurons in the rostral ventrolateral medulla. Competing hypotheses have been put forward by different investigators to explain the sympathoinhibition evoked by ''imidazoline drugs'': either via central actions at alpha(2)-adrenergic receptors or novel I-1-imidazoline receptors. These different perspectives are presented in the accompanying reviews.

引用

页码：R1569 / R1571

页数：3

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