A chemical adaptor system designed to link a tumor-targeting device with a prodrug and an enzymatic trigger

被引：57

作者：

Gopin, A ^{[1
]}

Pessah, N ^{[1
]}

Shamis, M ^{[1
]}

Rader, C ^{[1
]}

Shabat, D ^{[1
]}

机构：

[1] Tel Aviv Univ, Dept Organ Chem, Sch Chem, Fac Exact Sci, IL-69978 Tel Aviv, Israel

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 03期

关键词：

cancer therapy; catalytic antibodies; drug delivery systems; prodrugs; selective chemotherapy;

D O I：

10.1002/anie.200390108

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Targeting tumors can be achieved by using a novel chemical adaptor system (see picture) comprising, for example, the anticancer drug epotoside, an N-(2-hydroxypropyl) methacrylamide (HPMA) copolymer as the tumor-targeting device, and catalytic antibody 38C2 as the triggering enzyme in a single entity. When the enzyme cleaves the substrate, it triggers a spontaneous reaction that releases the active drug from the targeting moiety.

引用

页码：327 / +

页数：7

共 14 条

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