FGF-18 is a neuron-derived glial cell growth factor expressed in the rat brain during early postnatal development

被引：34

作者：

Hoshikawa, M ^{[1
]}

Yonamine, A ^{[1
]}

Konishi, M ^{[1
]}

Itoh, N ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Pharmaceut Sci, Dept Biochem Genet, Kyoto 6068501, Japan

来源：

MOLECULAR BRAIN RESEARCH | 2002年 / 105卷 / 1-2期

关键词：

fibroblast growth factor (FGF); neuron; astrocyte; microglia; brain; gliogenesis;

D O I：

10.1016/S0169-328X(02)00393-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We examined the expression of fibroblast growth factor-18 (FGF-18) in the rat brain during postnatal development by in situ hybridization. FGF-18 was transiently expressed at the early postnatal stages in various regions of the rat brain including the cerebral cortex and hippocampus. FGF-18 in the brain was preferentially expressed in neurons but not in glial cells. To elucidate the role of FGF-18 in the brain, we examined the ligand-specificity of FGF-18 by the BIAcore system. FGF-18 was found to bind to FGF receptors (FGFRs)-3c and -2c but not to FGFR-1c, suggesting that FGF-18 acts on glial cells but not on neurons. Therefore, we examined the mitogenic activity of FGF-18 for cultured rat astrocytes and microglia. FGF-18 was found to have mitogenic activity for both astrocytes and microglia. We also examined the neurotrophic activity of FGF-18 for cultured rat cortical neurons. FGF-18 was found to have no neurotrophic activity. The present findings indicated that FGF-18 is a unique FGF that plays a role as a neuron-derived glial cell growth factor in early postnatal development when gliogenesis occurs. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：60 / 66

页数：7

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