Lymphatic System in Cardiovascular Medicine

被引：281

作者：

Aspelund, Aleksanteri ^{[1
,2
]}

Robciuc, Marius R. ^{[1
,2
]}

Karaman, Sinem ^{[1
]}

Makinen, Taija ^{[3
]}

Alitalo, Kari ^{[1
,2
]}

机构：

[1] Univ Helsinki, Wihuri Res Inst, Biomedicum Helsinki, POB 63,Haartmaninkatu 8, FIN-00014 Helsinki, Finland

[2] Univ Helsinki, Translat Canc Biol Program, Biomedicum Helsinki, POB 63,Haartmaninkatu 8, FIN-00014 Helsinki, Finland

[3] Uppsala Univ, Dept Immunol Genet & Pathol, Uppsala, Sweden

来源：

CIRCULATION RESEARCH | 2016年 / 118卷 / 03期

基金：

瑞士国家科学基金会; 芬兰科学院; 欧洲研究理事会;

关键词：

cardiovascular diseases; lymphangiogenesis; vascular endothelial growth factor C; vascular endothelial growth factor receptor-3; endothelial cells; GROWTH-FACTOR RECEPTOR-3; VEGF-C; ENDOTHELIAL-CELLS; PRIMARY LYMPHEDEMA; VESSEL MATURATION; ECTODERMAL DYSPLASIA; VASCULAR DEVELOPMENT; INTERSTITIAL FLUID; INTESTINAL LACTEAL; VALVE DEVELOPMENT;

D O I：

10.1161/CIRCRESAHA.115.306544

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

The mammalian circulatory system comprises both the cardiovascular system and the lymphatic system. In contrast to the blood vascular circulation, the lymphatic system forms a unidirectional transit pathway from the extracellular space to the venous system. It actively regulates tissue fluid homeostasis, absorption of gastrointestinal lipids, and trafficking of antigen-presenting cells and lymphocytes to lymphoid organs and on to the systemic circulation. The cardinal manifestation of lymphatic malfunction is lymphedema. Recent research has implicated the lymphatic system in the pathogenesis of cardiovascular diseases including obesity and metabolic disease, dyslipidemia, inflammation, atherosclerosis, hypertension, and myocardial infarction. Here, we review the most recent advances in the field of lymphatic vascular biology, with a focus on cardiovascular disease.

引用

页码：515 / 530

页数：16

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