Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome

被引：783

作者：

Maury, E. ^{[1
]}

Brichard, S. M. ^{[1
]}

机构：

[1] Univ Louvain, Fac Med, Endocrinol & Metab Unit, B-1200 Brussels, Belgium

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2010年 / 314卷 / 01期

关键词：

Adipokines; Metabolic syndrome; Adipose tissue; Obesity; Inflammation; Adipocytes; NECROSIS-FACTOR-ALPHA; MONOCYTE CHEMOATTRACTANT PROTEIN-1; PLASMINOGEN-ACTIVATOR INHIBITOR-1; DIET-INDUCED OBESITY; FACTOR-KAPPA-B; INTERNATIONAL-DIABETES-FEDERATION; ENDOTHELIAL ADHESION MOLECULES; ENDOPLASMIC-RETICULUM STRESS; INDUCED INSULIN-RESISTANCE; RENIN-ANGIOTENSIN SYSTEM;

D O I：

10.1016/j.mce.2009.07.031

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Obesity plays a causative role in the pathogenesis of the metabolic syndrome. Adipokines may link obesity to its co-morbidities. Most adipokines with pro-inflammatory properties are overproduced with increasing adiposity, while some adipokines with anti-inflammatory or insulin-sensitizing properties, like adiponectin are decreased. This dysregulation of adipokine production may promote obesity-linked metabolic disorders and cardiovascular disease. Besides considering adipokines, this review will also highlight the cellular key players and molecular mechanisms involved in adipose inflammation. Targeting the changes in the cellular composition of adipose tissue, the underlying molecular mechanisms, and the altered production of adipokines may have therapeutic potential in the management of the metabolic syndrome. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

引用

页码：1 / 16

页数：16

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