The paired-pulse index: A measure of hippocampal dentate granule cell modulation

被引：23

作者：

Bronzino, JD ^{[1
]}

Blaise, JH ^{[1
]}

Morgane, PJ ^{[1
]}

机构：

[1] UNIV NEW ENGLAND,BIDDEFORD,ME

来源：

ANNALS OF BIOMEDICAL ENGINEERING | 1997年 / 25卷 / 05期

关键词：

hippocampal formation; hippocampal dentate granule cell; hippocampal dentate gyrus; facilitation; GABA-ergic inhibition; normal development; evoked response;

D O I：

10.1007/BF02684171

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

This study was undertaken to assess whether the paired-pulse index (PPI) is an effective measure of the modulation of dentate granule cell excitability during normal development. Paired-pulse stimulations of the perforant path were, therefore, used to construct a PPI for 15-, 30-, and 90-day old, freely moving male rats. Significant age-dependent differences in the PPI were obtained. Fifteen-day old rats showed significantly less inhibition at short interpulse intervals [interpulse interval (IPI): 20 to 30 msec), a lack of facilitation at intermediate IPIs (50 to 150 msec), and significantly less inhibition at longer IPIs (300 to 1,000 msec) than adults.

引用

页码：870 / 873

页数：4

共 12 条

[1]

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[2]

BECKENSTEIN JW, 1991, DEV BRAIN RES, V63, P245

[3] EFFECTS OF PRENATAL PROTEIN-MALNUTRITION ON KINDLING-INDUCED ALTERATIONS IN DENTATE GRANULE CELL EXCITABILITY .2. PAIRED-PULSE MEASURES [J].