DNA damage in horticultural farmers: a pilot study showing an association with organophosphate pesticide exposure

被引：37

作者：

Atherton, Kathryn M. ^{[1
,2
]}

Williams, Faith M. ^{[1
,2
]}

Gonzalez, Francisco J. Egea ^{[3
]}

Glass, Richard ^{[4
]}

Rushton, Steve ^{[1
]}

Blain, Peter G. ^{[2
]}

Mutch, Elaine ^{[1
,2
]}

机构：

[1] Newcastle Univ, Inst Res Environm & Sustainabil, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

[2] Med Toxicol Ctr, Wolfson Unit, Newcastle Upon Tyne, Tyne & Wear, England

[3] Univ Almeria, Dept Analyt Chem, Almeria, Spain

[4] Cent Sci Lab, York, N Yorkshire, England

来源：

BIOMARKERS | 2009年 / 14卷 / 07期

关键词：

Acetylcholinesterase; 8-hydroxy-2 '-deoxyguanosine; organophosphate pesticides; GEL-ELECTROPHORESIS ASSAY; COMET ASSAY; MONONUCLEAR LEUKOCYTES; OXIDATIVE STRESS; WORKERS; GENOTOXICITY; URINE;

D O I：

10.3109/13547500903137265

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A study of horticultural farmers exposed to organophosphate pesticides (OPs) and controls investigated the relationships between OP exposure, DNA damage and oxidative stress. Blood acetylcholinesterase (AChE) and urinary dialkylphosphate (DAP) levels determined exposure and 8-hydroxy-2'-deoxyguanosine (8OHdG) indicated oxidative stress status. The farmers had approximately 30% lower AChE activity and increased DAP levels compared with the controls, reflecting moderate OP exposure. They had higher DNA damage than the controls and there was a significant positive relationship between DAP and DNA damage with greater than 95% power. The farmers also had a significant positive relationship between urinary DAP and 8OHdG levels.

引用

页码：443 / 451

页数：9

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