Knockout mice: A paradigm shift in modern immunology

被引：51

作者：

Mak, TW

Penninger, JM

Ohashi, PS

机构：

[1] Univ Toronto, Amgen Res Inst, Toronto, ON M5G 2M9, Canada

[2] Univ Toronto, Ontario Canc Inst, Toronto, ON M5G 2M9, Canada

[3] Univ Toronto, Dept Med Biophys, Toronto, ON M5G 2M9, Canada

[4] Univ Toronto, Dept Immunol, Toronto, ON M5G 2M9, Canada

来源：

NATURE REVIEWS IMMUNOLOGY | 2001年 / 1卷 / 01期

关键词：

D O I：

10.1038/35095551

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In the past decade, advances in genetic engineering and mouse knockout technology have transformed our understanding of the immune system. In particular, new perspectives on T-cell development, co-stimulation and activation have emerged from the study of single and multiple gene-knockout animals, as well as from conditional knockout and 'knock-in' mutants. Analysis of these animals has clarified important intracellular signalling pathways and has shed light on the regulatory mechanisms that govern normal immune responses and autoimmunity.

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页码：11 / 19

页数：9

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