GOLPH2 Gene Markers are Not Associated with Alzheimer's Disease in a Sample of the Spanish Population

被引：7

作者：

Antunez, Carmen ^{[1
,2
]}

Boada, Merce ^{[3
]}

Lopez-Arrieta, Jesus ^{[4
]}

Ramirez-Lorca, Reposo ^{[5
]}

Hernandez, Isabel

Marin, Juan ^{[1
]}

Martinez-Lage, Pablo

Gonzalez-Perez, Antonio ^{[5
]}

Jorge Galan, Jose ^{[5
]}

Gayan, Javier ^{[5
]}

Real, Luis M. ^{[5
]}

Ruiz, Agustin ^{[5
]}

机构：

[1] Univ Hosp Virgen Arrixaca, Dementia Unit, Murcia, Spain

[2] AlzheimUr Fdn, Murcia, Spain

[3] Univ Gen Hosp Vall Hebron, Neurol Serv, Barcelona, Spain

[4] Univ Hosp La Paz Cantoblanco, Memory Unit, Madrid, Spain

[5] NeoCodex, Dept Struct Genom, Seville, Spain

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2009年 / 18卷 / 04期

关键词：

Alzheimer's disease; complex diseases; genetic susceptibility; Genome Wide Association Studies (GWAS); GOLPH2; human molecular genetics; neurodegeneration; GENOME SCREEN;

D O I：

10.3233/JAD-2009-1200

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

GOLPH2 gene SNP variants Rs10868366 and Rs7019241 were reported to decrease the risk of Alzheimer's disease in a recent Whole Genome Association Study. We have investigated these genetic variants in 2470 individuals from Spain to conduct an independent replication study of the proposed SNP markers. We found no evidence of association between GOLPH2 markers and susceptibility to Alzheimer's disease in our series. We concluded that GOLPH2 gene does not contribute to risk of disease in this study sample.

引用

页码：751 / 754

页数：4

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