Distribution of Human Papillomavirus Type 58 Variants in Progression of Cervical Dysplasia in Korean Women

被引:12
作者
Bae, Jeong-Hoon [1 ]
Cheung, Jo L. K. [2 ]
Lee, Sung-Jong [1 ]
Luk, Alfred C. S. [2 ]
Tong, Seo-Yun [3 ]
Chan, Paul K. S. [2 ]
Park, Jong-Sup [1 ]
机构
[1] Catholic Univ Korea, Dept Obstet & Gynecol, Seoul 137040, South Korea
[2] Chinese Univ Hong Kong, Dept Microbiol, Hong Kong, Hong Kong, Peoples R China
[3] Kyung Hee Univ, Sch Med, EW Neo Med Ctr, Dept Obstet & Gynecol, Seoul 134727, South Korea
关键词
Human papillomavirus (HPV); cervical intraepithelial neoplasia (CIN); HPV variants; GENOTYPE DISTRIBUTION; WORLDWIDE; LESIONS; CANCER; GENE; CYTOLOGY; HPV16;
D O I
10.4014/jmb.0812.679
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
This cross-sectional study examined the distribution of HPV 58 sequence variation in Korean women for the first time. Among 1,750 Korean women, 53 women were positive for HPV 58 single infection, of whom 26 were without disease, 20 were with cervical intraepithelial neoplasia (CIN) 1, and 7 with CIN 2 or 3. Altogether, 36 different nucleotide sequence variations were identified with the L1, 20 within E2, 5 within E6, and 10 within E7. Further studies on variants of oncogenic HPVs are necessary, particularly for the purpose of developing more predictive HPV detection methods.
引用
收藏
页码:1051 / 1054
页数:4
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