VIEWPOINT Induced pluripotent stem cells and reprogramming: seeing the science through the hype

被引：72

作者：

Belmonte, Juan Carlos Izpisua ^{[1
,2
]}

Ellis, James ^{[3
,4
]}

Hochedlinger, Konrad ^{[5
,6
,7
]}

Yamanaka, Shinya ^{[8
]}

机构：

[1] Ctr Regenerat Med Barcelona, Barcelona 08003, Spain

[2] Salk Inst Biol Studies, La Jolla, CA 93027 USA

[3] Hosp Sick Children, Toronto, ON M5G 1L7, Canada

[4] MaRS Ctr, Ontario Human iPS Cell Facil, Toronto, ON M5G 1L7, Canada

[5] Harvard Univ, Dept Stem Cell & Regenerat Biol, Cambridge, MA 02138 USA

[6] Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02114 USA

[7] Harvard Stem Cell Inst, Ctr Regenerat Med, Boston, MA 02114 USA

[8] Inst Frontier Med Sci, Dept Stem Cell Biol, Inst Integrated Cell Mat Sci iCeMS, Ctr iPS Cell Res & Applicat CiRA,Shogoin Sakyo Ku, Kyoto 6068507, Japan

来源：

NATURE REVIEWS GENETICS | 2009年 / 10卷 / 12期

关键词：

GENERATION;

D O I：

10.1038/nrg2700

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

No-one can have failed to notice the splash that induced pluripotent stem (iPS) cells have made in the few years since somatic cells were first reprogrammed to pluripotency. But what is their real promise, where should research efforts be focused, and are we at a stage where we can replace embryonic stem cells? Four pioneering iPS cell researchers offer their personal insights into these and other questions of current debate. As well expressing hope for the improved understanding and treatment of human disease, they urge caution over safety and propose the establishment of iPS cell banks.

引用

页码：878 / U80

页数：6

共 21 条

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