Modeling genetic and environmental influences in the etiology of conduct disorder: A study of 2,682 adult twin pairs

被引:161
作者
Slutske, WS [1 ]
Heath, AC [1 ]
Dinwiddie, SH [1 ]
Madden, PAF [1 ]
Bucholz, KK [1 ]
Dunne, MP [1 ]
Statham, DJ [1 ]
Martin, NG [1 ]
机构
[1] QUEENSLAND INST MED RES, EPIDEMIOL UNIT, BRISBANE, QLD 4006, AUSTRALIA
关键词
D O I
10.1037/0021-843X.106.2.266
中图分类号
B849 [应用心理学];
学科分类号
040203 ;
摘要
The etiology of conduct disorder (CD) was examined retrospectively in a sample of 2,682 male, female, and unlike-sex adult twin pairs from the community-based Australian Twin Register. Model-fitting analyses indicated a substantial genetic influence on risk for CD, accounting for 71% of the variance (95% confidence interval [CI] = 32-79%). There was not a statistically significant effect of the shared environment in the best-fitting model of CD, but a modest effect of the shared environment on the risk for CD could not be rejected (95% CI = 0-32%). The magnitude of generic and environmental influences for CD liability did not vary significantly for boys and girls, and the specific genetic and environmental mechanisms important for the development of CD appeared to be largely the same for both sexes. The fit of a multiple-threshold model raises the possibility that CD may not necessarily be a discrete entity but rather an extreme of the normal variation in conduct-disordered behavior found in the general population.
引用
收藏
页码:266 / 279
页数:14
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