TSH-Lowering Effect of Metformin in Type 2 Diabetic Patients Differences between euthyrold, untreated hypothyroid, and euthyrold on L-T4 therapy patients

被引：127

作者：

Cappelli, Carlo ^{[1
]}

Rotondi, Mario ^{[2
]}

Pirola, Ilenia ^{[1
]}

Agosti, Barbara ^{[3
]}

Gandossi, Elena ^{[1
]}

Valentini, Umberto ^{[3
]}

De Martino, Elvira ^{[1
]}

Cimino, Antonio ^{[3
]}

Chiovato, Luca ^{[2
]}

Agabiti-Rosei, Enrico ^{[1
]}

Castellano, Maurizio ^{[1
]}

机构：

[1] Univ Brescia, Internal Med & Endocrinol Unit, Dept Med & Surg Sci, Brescia, Italy

[2] Univ Pavia, Unit Internal Med & Endocrinol, Fdn Salvatore Maugeri,Lab Endocrine Disruptors, Ist Ricovero & Cura Carattere Sci,Ist Super Preve, I-27100 Pavia, Italy

[3] Spedali Civil Brescia, Diabet Unit, I-25125 Brescia, Italy

来源：

DIABETES CARE | 2009年 / 32卷 / 09期

关键词：

MELLITUS; WOMEN;

D O I：

10.2337/dc09-0273

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVE - To assess the interplay between metformin treatment and thyroid function in type 2 diabetic patients. RESEARCH DESIGN AND METHODS - The acute and long-term effects Of metformin on thyroid axis hormones were assessed in diabetic patients with primary hypothyroidism who were either untreated or treated With levothyroxine (L-T4), as well as in diabetic patients With normal thyroid function. RESULTS- No acute changes were found in 11 patients with treated hypothyroidism. After I year of metformin administration, a significant thyrotropin (TSH) decrease (P < 0.001) was observed in diabetic subjects with hypothyroidism who were either treated (n 29; from 2.37 +/- 1.17 to 1.41 +/- 1.21 mIU/l) or untreated (n = 18; 4.5 +/- 0.37 vs. 2.93 +/- 1.48) with L-T4, but not in 54 euthyroid Subjects. No significant change in free T4 (FT4) was observed in any group. CONCLUSIONS - Metformin administration influences TSH without change of FT4 in patients with type 2 diabetes and concomitant hypothyroidism. The need for reevaluation of thyroid function in these patients within 6-12 months after starting metformin is indicated.

引用

页码：1589 / 1590

页数：2

共 9 条

[1] Approaches to treatment of type 2 diabetes [J].