Catalytic antibodies as designer proteases and esterases

被引：77

作者：

Tanaka, F ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA

来源：

CHEMICAL REVIEWS | 2002年 / 102卷 / 12期

关键词：

D O I：

10.1021/cr010180a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Catalytic... This review describes monoclonal catalytic antibodies that catalyze the hydrolysis of ester, amide, carbonate, and carbamate. Focus is on aspects of hapten design, selection strategy, and their consequences. The purpose is to provide an understanding of how designer protein catalysts are created using the immune system.

引用

页码：4885 / 4906

页数：22

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