Stability of leukemia-associated immunophenotypes in precursor B-lymphoblastic leukemia/lymphoma - A single institution experience

被引：32

作者：

Chen, Weina ^{[1
]}

Karandikar, Nitin J. ^{[1
]}

McKenna, Robert W. ^{[1
]}

Kroft, Steven H. ^{[1
]}

机构：

[1] Univ Texas, SW Med Sch, Dallas, TX 75230 USA

来源：

AMERICAN JOURNAL OF CLINICAL PATHOLOGY | 2007年 / 127卷 / 01期

关键词：

flow cytometry; precursor B-lymphoblastic leukemia/lymphoma; precursor B-ALL; immunophenotypic stability; minimal residual disease;

D O I：

10.1309/7R6MU7R9YWJBY5V4

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Essentially all cases of precursor B-lymphoblastic leukemia/dymphoma (B-ALL) demonstrate multiple immunophenotypic aberrancies relative to normal maturing B-cell precursors (hematogones). The stability of these aberrancies has relevance to follow-up minimal residual disease analysis. We compared the immunophenotypes at diagnosis and relapse in 51 childhood and adult B-ALLs with flow cytometry (FC) using broad antibody; panels. A total of 446 aberrancies were present at diagnosis (median, 9 per case; range, 2-14). All cases retained multiple aberrancies at relapse (median, 8 per case; range, 2-14). Antibody panels at relapse allowed assessment of 383 (85.9%) of the initial 446 aberrancies. Of these, 299 (78.1%)were persistent and 84 (21.9%) were lost at relapse. Overall, 73% of cases showed a loss of at least I aberrancy at relapse. However new aberrancies were detected in 60% of cases. These findings suggest that FC is suitable for the detection of residual B-ALL, provided that follow-up studies are not too narrowly targeted.

引用

页码：39 / 46

页数：8

共 29 条

[1]

ABSHIRE TC, 1992, LEUKEMIA, V6, P357

[2] ANALYSIS OF IG AND T-CELL RECEPTOR GENES IN 40 CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIAS AT DIAGNOSIS AND SUBSEQUENT RELAPSE - IMPLICATIONS FOR THE DETECTION OF MINIMAL RESIDUAL DISEASE BY POLYMERASE CHAIN-REACTION ANALYSIS [J].