Intramolecular Mannich reaction of 2-oxotryptamine and homologues with oxo reagents yielding spiro compounds.: Part II

被引：7

作者：

Dörnyei, G ^{[1
]}

Incze, M ^{[1
]}

Kajtár-Peredy, M ^{[1
]}

Szántay, C ^{[1
]}

机构：

[1] Hungarian Acad Sci, Chem Res Ctr, Inst Chem, H-1025 Budapest 2, Hungary

来源：

COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS | 2002年 / 67卷 / 11期

关键词：

intramolecular Mannich reaction; spirocyclic compounds; oxindoles; pyrrolidines; piperidines; cyclizations; alkaloids; ketones; indoles;

D O I：

10.1135/cccc20021669

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

2-Oxotryptamine and its homo derivative undergo intramolecular Mannich-type cyclization with acetone and other ketones to give spiro[indole-3,3'-pyrrolidin]-2-ones and spiro[indole-3,3'-piperidin]-2-ones. A similar reaction with the bis-homologue of 2-oxotryptamine to yield spiro[ azepane-3,3'-indol]-2-ones was unsuccessful.

引用

页码：1669 / 1680

页数：12

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